Asmail Muftah, SM Shermer, Frank C Langbein. Texture Feature Analysis for Classification of Early-Stage Prostate Cancer in mpMRI. Proc AI in Healthcare (AIiH), Swansea, UK, September 2024.
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[arXiv:2406.15571]
Magnetic resonance imaging (MRI) has become a crucial tool in the diagnosis and staging of prostate cancer, owing to its superior tis- sue contrast. However, it also creates large volumes of data that must be assessed by trained experts, a time-consuming and laborious task. This has prompted the development of machine learning tools for the automation of Prostate cancer (PCa) risk classification based on multi- ple MRI modalities (T2W, ADC, and high-b-value DWI). Understanding and interpreting the predictions made by the models, however, remains a challenge. We analyze Random Forests (RF) and Support Vector Ma- chines (SVM), for two complementary datasets, the public Prostate-X dataset, and an in-house, mostly early-stage PCa dataset to elucidate the contributions made by first-order statistical features, Haralick tex- ture features, and local binary patterns to the classification. Using cor- relation analysis and Shapley impact scores, we find that many of the features typically used are strongly correlated, and that the majority of features have negligible impact on the classification. We identify a small set of features that determine the classification outcome, which may aid the development of explainable AI approaches.
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